A compendium of genetic regulatory effects across pig tissues

J Teng, Y Gao, H Yin, Z Bai, S Liu, H Zeng… - Nature …, 2024 - nature.com
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

[HTML][HTML] Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations

D Kumar, SS Sahoo, D Chauss, M Kazemian… - Journal of …, 2023 - Elsevier
Immune cell function is critically dependent on precise control over transcriptional output
from the genome. In this respect, integration of environmental signals that regulate gene …

eRNAbase: a comprehensive database for decoding the regulatory eRNAs in human and mouse

C Song, G Zhang, X Mu, C Feng, Q Zhang… - Nucleic Acids …, 2024 - academic.oup.com
Enhancer RNAs (eRNAs) transcribed from distal active enhancers serve as key regulators in
gene transcriptional regulation. The accumulation of eRNAs from multiple sequencing …

[HTML][HTML] Enhancer RNAs (eRNAs) in cancer: the jacks of all trades

S Napoli, N Munz, F Guidetti, F Bertoni - Cancers, 2022 - mdpi.com
Simple Summary This review focuses on eRNAs and the several mechanisms by which they
can regulate gene expression. In particular we describe here the most recent examples of …

Comprehensive characterization of the transcriptional landscape in Alzheimer's disease (AD) brains

C Chen, Z Zhang, Y Liu, W Hong, H Karahan… - Science …, 2025 - science.org
Alzheimer's disease (AD) is the leading dementia among the elderly with complex origins.
Despite extensive investigation into the AD-associated protein-coding genes, the …

DeepITEH: a deep learning framework for identifying tissue-specific eRNAs from the human genome

T Zhang, L Li, H Sun, G Wang - Bioinformatics, 2023 - academic.oup.com
Motivation Enhancers are vital cis-regulatory elements that regulate gene expression.
Enhancer RNAs (eRNAs), a type of long noncoding RNAs, are transcribed from enhancer …

Constructing eRNA-mediated gene regulatory networks to explore the genetic basis of muscle and fat-relevant traits in pigs

C Wang, C Chen, B Lei, S Qin, Y Zhang, K Li… - Genetics Selection …, 2024 - Springer
Abstract Background Enhancer RNAs (eRNAs) play a crucial role in transcriptional
regulation. While significant progress has been made in understanding epigenetic …

Enhancer RNA SLIT2 inhibits bone metastasis of breast cancer through regulating P38 MAPK/c-Fos signaling pathway

P Li, Z Lin, Q Liu, S Chen, X Gao, W Guo, F Gong… - Frontiers in …, 2021 - frontiersin.org
Background Breast cancer (BRCA) is the most common cancer in women, while the bones
are one of the most common sites of metastasis. Although new diagnostic methods or …

[HTML][HTML] Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression

TY Hou, WL Kraus - Cell reports, 2022 - cell.com
To better understand the functions of non-coding enhancer RNAs (eRNAs), we annotated
the estrogen-regulated eRNA transcriptome in estrogen receptor α (ERα)-positive breast …

Bioinformatic characterization of ENPEP, the gene encoding a potential cofactor for SARS-CoV-2 infection

A Arppo, H Barker, S Parkkila - PLoS One, 2024 - journals.plos.org
Research on SARS-CoV-2, the viral pathogen that causes COVID-19, has identified
angiotensin converting enzyme 2 (ACE2) as the primary viral receptor. Several genes that …