The hedgehog (Hh) family comprises sonic hedgehog (Shh), Indian hedgehog (Ihh), and
desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

With complete coverage appropriate for residents through experienced pediatric
orthopaedic surgeons, Tachdjian's Pediatric Orthopaedics, 6th Edition, continues a 50-year …

Hereditary multiple exostoses, a dominantly inherited genetic disorder characterized by
multiple cartilaginous tumors, is caused by mutations in members of the EXT gene family …

Heparan sulfate (HS) proteoglycans are extended (-GlcAβ1, 4GlcNAcα1, 4-) n co-polymers
containing decorations of sulfation and epimerization that are linked to cell surface and …

Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by
the formation of cartilage-capped tumours (exostoses) that develop from the growth plate of …

Some details are inevitably lost when attempting to simplify subjects involving complex
medical genetics subjects. However, unless an attempt is made to distill such topics, busy …

Heparan sulfates are complex polysaccharides that mediate the interaction with a broad
range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is …

Hereditary multiple exostoses (EXT) is an autosomal dominant disorder characterized by the
formation of exostoses, which are cartilage‐capped bony protuberances mainly located on …

The solitary osteochondroma, a common pediatric bone tumor, is a cartilage-capped
exostosis. Hereditary multiple exostosis is an autosomal dominant disorder manifested by …