Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

The major forms of diabetes are characterized by pancreatic islet β-cell dysfunction and
decreased β-cell numbers, raising hope for cell replacement therapy. Although human islet …

Diabetes is associated with β cell failure. But it remains unclear whether the latter results
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …

The molecular clock maintains energy constancy by producing circadian oscillations of rate-
limiting enzymes involved in tissue metabolism across the day and night,,. During periods of …

Paneth cells are post-mitotic intestinal epithelial cells supporting the stem cell niche and
mucosal immunity. Paneth cell pathologies are observed in various gastrointestinal …

Summary Three-dimensional (3D) chromatin organization maps help dissect cell-type-
specific gene regulatory programs. Furthermore, 3D chromatin maps contribute to …

We demonstrate that conditional ablation of the homeobox transcription factor Cdx2 from
early endoderm results in the replacement of the posterior intestinal epithelium with …

The onset of pancreas development in the foregut endoderm is marked by activation of the
homeobox gene Pdx1 (IPF1). Pdx1 is essential for the expansion of the pancreatic …

Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other
hormones, and their abnormal function causes diabetes or hypoglycaemia. Here we …

OBJECTIVE Several transcription factors are essential to pancreatic islet β-cell
development, proliferation, and activity, including MafA and MafB. However, MafA and MafB …