Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that
leads to changes in life expectancy. In humans, ageing is characterized by greatly increased …

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways
is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we …

While autophagy genes are required for lifespan of long-lived animals, their tissue-specific
roles in aging remain unclear. Here, we inhibited autophagy genes in Caenorhabditis …

Motor neurons (MNs) constitute an ancient cell type targeted by multiple adult-onset
diseases. It is therefore important to define the molecular makeup of adult MNs in animal …

Organismal aging involves functional declines in both somatic and reproductive tissues.
Multiple strategies have been discovered to extend lifespan across species. However, how …

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-
cell transcriptome atlas profiling> 20 million cells from 623 mouse tissues across different life …

Understanding mechanisms of ageing remains a complex challenge for biogerontologists,
but recent adaptations of evolutionary ageing theories offer a compelling lens in which to …

The aging process is inherently complex, involving multiple mechanisms that interact at
different biological scales. The nematode Caenorhabditis elegans is a simple model …

Age‐related vision loss caused by retinal neurodegenerative pathologies is becoming more
prevalent in our ageing society. To understand the physiological and molecular impact of …

Fast axonal transport is crucial for neuronal function and is driven by kinesins and
cytoplasmic dynein. Here, we investigated the role of kinesin-1 in dense core vesicle (DCV) …