The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

LJ Howe, MG Nivard, TT Morris, AF Hansen… - Nature …, 2022 - nature.com
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …

[PDF][PDF] Mating Order Establishes Male Size Advantage in the Polygynandrous Millipede Centrobolus inscriptus Attems, 1928

M Cooper - New Visions in Biological Science, 2022 - researchgate.net
ABSTRACT A forest species of millipede belonging to the Order Spirobolida found along the
eastern coast of southern Africa were tested for size assortative mating. The objectives …

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

P Wainschtein, D Jain, Z Zheng, LA Cupples… - Nature …, 2022 - nature.com
Analyses of data from genome-wide association studies on unrelated individuals have
shown that, for human traits and diseases, approximately one-third to two-thirds of …

Variable prediction accuracy of polygenic scores within an ancestry group

H Mostafavi, A Harpak, I Agarwal, D Conley… - elife, 2020 - elifesciences.org
Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …

Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits

TB Horwitz, JV Balbona, KN Paulich… - Nature Human …, 2023 - nature.com
Positive correlations between mates can increase trait variation and prevalence, as well as
bias estimates from genetically informed study designs. While past studies of similarity …

Why do we pick similar mates, or do we?

TMM Versluys, A Mas-Sandoval… - Biology …, 2021 - royalsocietypublishing.org
Humans often mate with those resembling themselves, a phenomenon described as positive
assortative mating (PAM). The causes of this attract broad interest, but there is little …

Interpreting population-and family-based genome-wide association studies in the presence of confounding

C Veller, GM Coop - PLoS Biology, 2024 - journals.plos.org
A central aim of genome-wide association studies (GWASs) is to estimate direct genetic
effects: the causal effects on an individual's phenotype of the alleles that they carry …

Overcoming attenuation bias in regressions using polygenic indices

H van Kippersluis, P Biroli, R Dias Pereira… - Nature …, 2023 - nature.com
Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in
regression models. We analyze and compare two approaches addressing this attenuation …

Within-sibship GWAS improve estimates of direct genetic effects

LJ Howe, MG Nivard, TT Morris, AF Hansen… - BioRxiv, 2021 - biorxiv.org
Estimates from genome-wide association studies (GWAS) represent a combination of the
effect of inherited genetic variation (direct effects), demography (population stratification …