The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …
effects of inherited variation (direct effects), demography (population stratification …
[PDF][PDF] Mating Order Establishes Male Size Advantage in the Polygynandrous Millipede Centrobolus inscriptus Attems, 1928
M Cooper - New Visions in Biological Science, 2022 - researchgate.net
ABSTRACT A forest species of millipede belonging to the Order Spirobolida found along the
eastern coast of southern Africa were tested for size assortative mating. The objectives …
eastern coast of southern Africa were tested for size assortative mating. The objectives …
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
Analyses of data from genome-wide association studies on unrelated individuals have
shown that, for human traits and diseases, approximately one-third to two-thirds of …
shown that, for human traits and diseases, approximately one-third to two-thirds of …
Variable prediction accuracy of polygenic scores within an ancestry group
Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …
based on genome-wide association studies (GWAS) for phenotypic prediction. However …
Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits
Positive correlations between mates can increase trait variation and prevalence, as well as
bias estimates from genetically informed study designs. While past studies of similarity …
bias estimates from genetically informed study designs. While past studies of similarity …
Why do we pick similar mates, or do we?
Humans often mate with those resembling themselves, a phenomenon described as positive
assortative mating (PAM). The causes of this attract broad interest, but there is little …
assortative mating (PAM). The causes of this attract broad interest, but there is little …
Interpreting population-and family-based genome-wide association studies in the presence of confounding
A central aim of genome-wide association studies (GWASs) is to estimate direct genetic
effects: the causal effects on an individual's phenotype of the alleles that they carry …
effects: the causal effects on an individual's phenotype of the alleles that they carry …
Overcoming attenuation bias in regressions using polygenic indices
Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in
regression models. We analyze and compare two approaches addressing this attenuation …
regression models. We analyze and compare two approaches addressing this attenuation …
Within-sibship GWAS improve estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) represent a combination of the
effect of inherited genetic variation (direct effects), demography (population stratification …
effect of inherited genetic variation (direct effects), demography (population stratification …