In recent years, there have been a growing number of small and large molecules that could
be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can …

Nanomedicine is currently focused on the design and development of nanocarriers that
enhance drug delivery to the brain to address unmet clinical needs for treating …

We overviewed the anatomy and physiology of the nose-to-brain pathway, along with the
mechanisms involved. We then summarized the interaction process between nanoparticles …

Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …

Alzheimer's disease (AD) is the most common cause of memory disruption in elderly
subjects, with the prevalence continuing to rise mainly because of the aging world …

Biotechnology-based therapeutics include a wide range of products, such as recombinant
hormones, stem cells, therapeutic enzymes, monoclonal antibodies, genes, vaccines …

Alzheimer's disease (AD) is a global health crisis, one of the most complex
neurodegenerative diseases that significantly affects populations worldwide without any age …

Central nervous system diseases negatively affect patients and society. Providing successful
noninvasive treatments for these diseases is challenging because of the presence of the …

Clozapine (CZP) is an atypical antipsychotic, the most effective for the treatment of resistant
schizophrenia. With the aim of overcome the limitations of current dosage forms (tablets or …

Poly (D, L-lactide-co-glycolide)(PLGA) has emerged as a cornerstone in the development of
advanced drug delivery systems, particularly for intranasal and pulmonary routes. Its …