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The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia
Summary N 6-Methyladenosine (m 6 A) modification and its modulators play critical roles
and show promise as therapeutic targets in human cancers, including acute myeloid …
and show promise as therapeutic targets in human cancers, including acute myeloid …
m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer
W Wan, X Ao, Q Chen, Y Yu, L Ao, W ** techniques to detect modified nucleotides has revealed …
The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q **ong, Z **… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
A comprehensive review of m6A/m6Am RNA methyltransferase structures
S Oerum, V Meynier, M Catala, C Tisné - Nucleic acids research, 2021 - academic.oup.com
Gene expression is regulated at many levels including co-or post-transcriptionally, where
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
Neutrophil extracellular traps mediate m6A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells
H Zhang, J Liu, Y Zhou, M Qu, Y Wang… - … journal of biological …, 2022 - pmc.ncbi.nlm.nih.gov
Neutrophil extracellular traps (NETs) production is a major strategy employed by
polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been …
polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been …