The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders

G Sanacora, Z Yan, M Popoli - Nature Reviews Neuroscience, 2022 - nature.com
Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

[HTML][HTML] Laboratory models of post-traumatic stress disorder: The elusive bridge to translation

JE Dunsmoor, JM Cisler, GA Fonzo, SK Creech… - Neuron, 2022 - cell.com
Post-traumatic stress disorder (PTSD) is a debilitating mental illness composed of a
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …

Stress, microRNAs, and stress-related psychiatric disorders: an overview

L Musazzi, J Mingardi, A Ieraci, A Barbon… - Molecular …, 2023 - nature.com
Stress is a major risk factor for psychiatric disorders. During and after exposure to stressors,
the stress response may have pro-or maladaptive consequences, depending on several …

Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury

A Bangar, H Khan, A Kaur, K Dua, TG Singh - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Stroke is one of the leading causes of death and disability.
The only FDA-approved therapy for treating stroke is tissue plasminogen activator (tPA) …

Changes in the serum concentration levels of serotonin, tryptophan and cortisol among stress-resilient and stress-susceptible individuals after experiencing traumatic …

EA Ogłodek - International Journal of Environmental Research and …, 2022 - mdpi.com
Background: Stress is a common response to many environmental adversities. However,
once dysregulated, this reaction can lead to psychiatric illnesses, such as post-traumatic …

[HTML][HTML] Epigenetic mechanisms impacted by chronic stress across the rodent lifespan

A Dion, PT Muñoz, TB Franklin - Neurobiology of Stress, 2022 - Elsevier
Exposures to stress at all stages of development can lead to long-term behavioural effects,
in part through changes in the epigenome. This review describes rodent research …

[HTML][HTML] MicroRNAs in learning and memory and their impact on Alzheimer's disease

IF Wang, PC Ho, KJ Tsai - Biomedicines, 2022 - mdpi.com
Learning and memory formation rely on the precise spatiotemporal regulation of gene
expression, such as microRNA (miRNA)-associated silencing, to fine-tune gene expression …

Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats

MT Zanda, G Floris, SE Daws - Translational psychiatry, 2023 - nature.com
Recovery from opioid use disorder (OUD) and maintenance of abstinence from opioid use is
hampered by perseverant drug cravings that may persist for months after cessation of drug …

[HTML][HTML] Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p is associated with modulation of BDNF and FKBP5 in brain areas of PTSD-related susceptible …

OM Maurel, SA Torrisi, C Barbagallo… - International journal of …, 2021 - mdpi.com
Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder occurring in susceptible
individuals following a traumatic event. Understanding the mechanisms subserving trauma …

Sex differences in acute early life stress‐enhanced fear learning in adult rats

BL Minshall, RA Skipper, CA Riddle… - Developmental …, 2024 - Wiley Online Library
Patients diagnosed with posttraumatic stress disorder (PTSD) present with a spectrum of
debilitating anxiety symptoms resulting from exposure to trauma. Women are twice as likely …