Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

N Sestakova, A Puzserova, M Kluknavsky… - Interdisciplinary …, 2013 - sciendo.com
In various areas of the bio-medical, pharmacological and psychological research a multitude
of behavioural tests have been used to investigate the effects of environmental, genetic and …

A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Map** the way forward

G De Brouwer, A Fick, BH Harvey… - Cognitive, Affective, & …, 2019 - Springer
Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or
measure to study anxiety-and compulsive-like behaviors or anxiolytic and anticompulsive …

Nitric oxide and major depression

A Dhir, SK Kulkarni - Nitric oxide, 2011 - Elsevier
Nitric oxide has been known to play a significant role in the pathophysiology of various
disorders of the body. Despite its very short half-life, nitric oxide is known to modulate …

Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system

S Amiri, A Haj-Mirzaian, M Rahimi-Balaei, A Razmi… - Physiology & …, 2015 - Elsevier
Approximately more than 50% of patients with depression have the co-occurrence of
anxiety, which complicates the treatment of disease. Recently, social isolation stress (SIS) …

Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling …

NB Gawali, VD Bulani, MS Gursahani, PS Deshpande… - Brain research, 2017 - Elsevier
Agmatine, a neurotransmitter/neuromodulator, has shown to exert numerous effects on the
CNS. Chronic stress is a risk factor for development of depression, anxiety and deterioration …

Pathobiological targets of depression

K Chopra, B Kumar, A Kuhad - Expert opinion on therapeutic …, 2011 - Taylor & Francis
Introduction: Depression is one of the most prevalent and life-threatening forms of mental
illness associated with significant disability and mortality. About 21% of the world's …

Nitric oxide synthase inhibitors as antidepressants

G Wegener, V Volke - Pharmaceuticals, 2010 - mdpi.com
Affective and anxiety disorders are widely distributed disorders with severe social and
economic effects. Evidence is emphatic that effective treatment helps to restore function and …

Potential role of dietary nitrate in relation to cardiovascular and cerebrovascular health, cognition, cognitive decline and dementia: a review

A Rajendra, NP Bondonno, SR Rainey-Smith… - Food & function, 2022 - pubs.rsc.org
There is currently no effective treatment for dementia, of which Alzheimer's disease (AD) is
the most common form. It is, therefore, imperative to focus on evidence-based preventive …

Nitric oxide signalling and antidepressant action revisited

SRL Joca, AG Sartim, AL Roncalho, CFA Diniz… - Cell and tissue …, 2019 - Springer
Studies about the pathogenesis of mood disorders have consistently shown that multiple
factors, including genetic and environmental, play a crucial role on their development and …

Probiotic supplementation alleviates absence seizures and anxiety-and depression-like behavior in WAG/Rij rat by increasing neurotrophic factors and decreasing …

H Aygun, AT Akin, N Kızılaslan, O Sumbul… - Epilepsy & Behavior, 2022 - Elsevier
Aim Epilepsy is one of the most common chronic brain disorders that affect millions of
people worldwide. In the present study, we investigated the effects of probiotic …