Protein kinase CK2: a potential therapeutic target for diverse human diseases
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …
substrates, controls several signaling pathways, and is implicated in a plethora of human …
Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
Mining CK2 in cancer
Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and,
many cases, spread to other parts of the body. A protein historically involved in cancer is …
many cases, spread to other parts of the body. A protein historically involved in cancer is …
Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma
A major limitation of targeted cancer therapy is the rapid emergence of drug resistance,
which often arises through mutations at or downstream of the drug target or through intrinsic …
which often arises through mutations at or downstream of the drug target or through intrinsic …
Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage
B Peng, J Wang, Y Hu, H Zhao, W Hou… - Nucleic acids …, 2015 - academic.oup.com
Proper DNA damage response is essential for the maintenance of genome integrity. The E3
ligase RNF168 deficiency fully prevents both the initial recruitment and retention of 53BP1 at …
ligase RNF168 deficiency fully prevents both the initial recruitment and retention of 53BP1 at …
Understanding mammalian glutathione peroxidase 7 in the light of its homologs
The glutathione peroxidase homologs (GPxs) efficiently reduce hydroperoxides using
electrons from glutathione (GSH), thioredoxin (Trx), or protein disulfide isomerase (PDI). Trx …
electrons from glutathione (GSH), thioredoxin (Trx), or protein disulfide isomerase (PDI). Trx …
KDM1A identified as a potential oncogenic driver and prognostic biomarker via multi‐omics analysis
L Li, Y Wang, Y Mou, H Wu, Y Qin - Canadian Journal of …, 2021 - Wiley Online Library
Background. Lysine‐specific demethylase 1A (KDM1A) is a histone demethylation enzyme
and a crucial epigenetic factor for multiple pathological pathways that mediate …
and a crucial epigenetic factor for multiple pathological pathways that mediate …
Impact of protein kinase CK2 downregulation and inhibition on oncomir clusters 17~ 92 and 106b~ 25 in prostate, breast, and head and neck cancers
Background Protein kinase CK2 is a ubiquitous and highly conserved protein Ser/Thr kinase
with diverse cell functions. CK2 is upregulated in various cancers and affects numerous …
with diverse cell functions. CK2 is upregulated in various cancers and affects numerous …
The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis
Y Li, B Wang, Y Zheng, H Kang, A He, L Zhao, N Guo… - Genes & …, 2024 - Elsevier
Post-translational modifications (PTMs) of proteins play a crucial role in living organisms,
altering the properties and functions of proteins. There are over 450 known PTMs involved in …
altering the properties and functions of proteins. There are over 450 known PTMs involved in …
[HTML][HTML] Phosphorylation of LSD1 at serine 54 regulates genes involved in follicle selection by enhancing demethylation activity in chicken ovarian granulosa cells
Y Guo, Y Zhang, Y Wang, Q Chen, Y Sun, L Kang… - Poultry Science, 2024 - Elsevier
Follicle selection in chicken refers to the process of selecting a follicle to enter hierarchy from
a cohort of small yellow follicles (SY) with a diameter of 6 to 8 mm. The follicle being …
a cohort of small yellow follicles (SY) with a diameter of 6 to 8 mm. The follicle being …