Macrophages are endowed with a variety of receptors for lineage-determining growth
factors, T helper (Th) cell cytokines, and B cell, host, and microbial products. In tissues …

Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …

Background Human erythrocytes are terminally differentiated, anucleate cells long thought
to lack RNAs. However, previous studies have shown the persistence of many small-sized …

Emergence of new, pandemic-level viral threats has brought to the forefront the importance
of viral immunology and continued improvement of antiviral therapies. Interleukin-27 (IL-27) …

ABSTRACT A growing body of evidence suggests an essential role of the heterodimeric
cytokine, IL-27, for regulating immunity. IL-27 is composed of two subunits (p28 and EBI3) …

IL-27, a member of the IL-6/IL-12 cytokine superfamily, is primarily secreted by antigen
presenting cells, specifically by dendric cells, macrophages and B cells. IL-27 has antiviral …

Recreational and medical use of cannabis among human immunodeficiency virus (HIV)-
infected individuals has increased in recent years. In simian immunodeficiency virus (SIV) …

Abstract Interleukin (IL)-27, a member of the IL-6/IL-12 family, has an important role in
modulating inflammation in partnership with innate and adaptive immune cells. IL-27 …

Chronic viral infections represent a major challenge to the host immune response, and a
unique network of immunological elements, including cytokines, are required for their …

The innate immune system is important for the efficacy of vaccines, but excessive innate
immune responses can cause adverse reactions after vaccination. Extracellular vesicles …