Advances in hypoxia-inducible factor biology
Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
The role of cytokines in breast cancer development and progression
M Esquivel-Velázquez, P Ostoa-Saloma… - Journal of Interferon & …, 2015 - liebertpub.com
Cytokines are highly inducible, secretory proteins that mediate intercellular communication
in the immune system. They are grouped into several protein families that are referred to as …
in the immune system. They are grouped into several protein families that are referred to as …
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Increased expression of CD47 has been reported to enable cancer cells to evade
phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the …
phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the …
Regulation of breast cancer metastasis signaling by miRNAs
Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
[HTML][HTML] Integration of genomic and transcriptional features in pancreatic cancer reveals increased cell cycle progression in metastases
We integrated clinical, genomic, and transcriptomic data from 224 primaries and 95
metastases from 289 patients to characterize progression of pancreatic ductal …
metastases from 289 patients to characterize progression of pancreatic ductal …
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
SA Eccles, EO Aboagye, S Ali, AS Anderson… - Breast Cancer …, 2013 - Springer
Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
SREBP maintains lipid biosynthesis and viability of cancer cells under lipid-and oxygen-deprived conditions and defines a gene signature associated with poor …
Oxygen and nutrient limitation are common features of the tumor microenvironment and are
associated with cancer progression and induction of metastasis. The inefficient …
associated with cancer progression and induction of metastasis. The inefficient …
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization
Hypoxia-inducible factors (HIFs) activate transcription of target genes by recruiting
coactivators and chromatin-modifying enzymes. Peptidylarginine deiminase 4 (PADI4) …
coactivators and chromatin-modifying enzymes. Peptidylarginine deiminase 4 (PADI4) …
Hypoxia in breast cancer—scientific translation to therapeutic and diagnostic clinical applications
Y Zhang, H Zhang, M Wang, T Schmid, Z **n… - Frontiers in …, 2021 - frontiersin.org
Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral
hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is …
hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is …
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
M Morotti, E Bridges, A Valli… - Proceedings of the …, 2019 - National Acad Sciences
Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive
(ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming …
(ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming …