The incidence and mortality of cancer are the major health issue worldwide. Apart from the
treatments developed to date, the unsatisfactory therapeutic effects of cancers have not …

Transforming Growth Factor beta (TGF-β) is a pleiotropic cytokine produced in large
amounts within cancer microenvironments that will ultimately promote neoplastic …

Epigenetics connects genetic and environmental factors: it includes DNA methylation,
histone post‐translational modifications and the regulation of chromatin accessibility by non …

Endothelial mesenchymal transition (EndMT) has been described as a fundamental process
during embryogenesis; however, it can occur also in adult age, underlying pathological …

The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation
channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine …

Autoimmune uveitis is a non-infectious intraocular condition that affects the uveal tract of the
eye and threatens vision if not treated properly. Increasing evidence suggests that activated …

As a medicine-food homology (MFH) plant, golden-flowered tea (Camellia nitidissima Chi,
CNC) has many different pharmacologic activities and is known as “the queen of the tea …

Evidences highlight the role of various CD4+ helper T cells (CD4+ Th) subpopulations in
orchestrating the immune responses against cancers. Epigenetics takes an important part in …

Mesenchymal stem cells (MSCs) are widely investigated as potential therapeutic agents due
to their potent immunomodulatory capacity. Although specific mechanisms by which MSC …

Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which
endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic …