The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of
diabetes. Symptoms of DPN mainly include spontaneous intractable pain that is diffuse and …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, is the best known lipid mediator
that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …