Structural comparison reveals remote homology that often fails to be detected by sequence
comparison. The DALI web server (http://ekhidna2. biocenter. helsinki. fi/dali) is a platform …

The process of designing biomolecules, in particular proteins, is witnessing a rapid change
in available tooling and approaches, moving from design through physicochemical force …

In the medical, environmental, and biotechnological fields, microbial communities have
attracted much attention due to their roles and numerous possible applications. The study of …

Bacteria colonize every niche on Earth and play key roles in many environmental and host-
associated processes. The sequencing revolution revealed the remarkable bacterial genetic …

Motivation Thousands of genomes are publicly available, however, most genes in those
genomes have poorly defined functions. This is partly due to a gap between previously …

Automated annotations of protein functions are error-prone because of our lack of
knowledge of protein functions. For example, it is often impossible to predict the correct …

Premise The functional annotation of genes is a crucial component of genomic analyses. A
common way to summarize functional annotations is with hierarchical gene ontologies, such …

The availability of large databases of biological sequences presents an opportunity for in-
depth exploration of gene diversity and function. Bacterial defense systems are a rich source …

Anthocyanins are among the flavonoids that serve as the principal pigments affecting the
color of plants. During leaf growth, the leaf color of 'Zhonghuahongye'gradually changes …

Background Microbial eukaryotes play a crucial role in biochemical cycles and aquatic
trophic food webs. Their taxonomic and functional diversity are increasingly well described …