The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

Diagnosis of neonatal sepsis: the past, present and future

IH Celik, M Hanna, FE Canpolat, M Pammi - Pediatric research, 2022 - nature.com
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

Neonatal sepsis: a review of pathophysiology and current management strategies

MA Glaser, LM Hughes, A Jnah… - Advances in neonatal …, 2021 - journals.lww.com
Background: Early-onset sepsis, occurring within 72 hours of birth, and late-onset sepsis,
occurring after this time period, present serious risks for neonates. While culture-based …

The pathogenesis and diagnosis of sepsis post burn injury

P Zhang, B Zou, YC Liou, C Huang - Burns & trauma, 2021 - academic.oup.com
Burn is an under-appreciated trauma that is associated with unacceptably high morbidity
and mortality. Although the survival rate after devastating burn injuries has continued to …

Presepsin for the diagnosis of neonatal early-onset sepsis: a systematic review and meta-analysis

C Poggi, E Lucenteforte, D Petri, S De Masi… - JAMA …, 2022 - jamanetwork.com
Importance Neonatal early-onset sepsis (EOS) is a severe disease, particularly in preterm
infants. Timely diagnosis can be challenging owing to unspecific presentation and …

Relevance of biomarkers currently in use or research for practical diagnosis approach of neonatal early-onset sepsis

MA Hincu, GI Zonda, GD Stanciu, D Nemescu… - Children, 2020 - mdpi.com
Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first
72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up …

Biomarkers for point-of-care diagnosis of sepsis

A Teggert, H Datta, Z Ali - Micromachines, 2020 - mdpi.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. In 2017, almost 50 million cases of sepsis were recorded worldwide …

Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis

SH Yoon, EH Kim, HY Kim, JG Ahn - BMC Infectious Diseases, 2019 - Springer
Background Early diagnosis of sepsis in pediatric patients is vital but remains a major
challenge. Previous studies showed that presepsin is potentially a reliable diagnostic …

Advancement in biomarker based effective diagnosis of neonatal sepsis

N Gopal, N Chauhan, U Jain, SK Dass… - Artificial Cells …, 2023 - Taylor & Francis
Neonatal sepsis is considered as alarming medical emergency and becomes the common
global reason of neonatal mortality. Non-specific symptoms and limitations of conventional …

The emerging role of presepsin (P-SEP) in the diagnosis of sepsis in the critically ill infant: a literature review

C Maddaloni, DU De Rose, A Santisi, L Martini… - International journal of …, 2021 - mdpi.com
Sepsis causes high rates of morbidity and mortality in NICUs. The estimated incidence
varies between 5 and 170 per 1000 births, depending on the social context. In very low birth …