Review on plant antimicrobials: a mechanistic viewpoint

B Khameneh, M Iranshahy, V Soheili… - … Resistance & Infection …, 2019 - Springer
Microbial resistance to classical antibiotics and its rapid progression have raised serious
concern in the treatment of infectious diseases. Recently, many studies have been directed …

Antimicrobials from medicinal plants: an emergent strategy to control oral biofilms

C Milho, J Silva, R Guimarães, ICFR Ferreira… - Applied Sciences, 2021 - mdpi.com
Oral microbial biofilms, directly related to oral diseases, particularly caries and periodontitis,
exhibit virulence factors that include acidification of the oral microenvironment and the …

Caffeic acid prevents vascular oxidative stress and atherosclerosis against atherosclerogenic diet in rats

Y Wang, G Kaur, M Kumar, AS Kushwah… - Evidence‐Based …, 2022 - Wiley Online Library
Diet and lifestyle play a crucial role in the progress of some cardiovascular disorders
(CVDs). Rising interest in natural products and their pharmacological investigations …

An assessment of the in vitro models and clinical trials related to the antimicrobial activities of phytochemicals

J Kopel, J McDonald, A Hamood - Antibiotics, 2022 - mdpi.com
An increased number antibiotic-resistant bacteria have emerged with the rise in antibiotic
use worldwide. As such, there has been a growing interest in investigating novel antibiotics …

Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans

J Dominguez, AI Mendes, AR Pacheco… - Frontiers in …, 2023 - frontiersin.org
Mycobacterium ulcerans causes Buruli Ulcer, a neglected infectious skin disease that
typically progresses from an early non-ulcerative lesion to an ulcer with undermined edges …

Pharmacometabolomics for the study of lipid-lowering therapies: opportunities and challenges

E Gianazza, M Brioschi, A Iezzi, G Paglia… - International Journal of …, 2023 - mdpi.com
Lipid-lowering therapies are widely used to prevent the development of atherosclerotic
cardiovascular disease (ASCVD) and related mortality worldwide.“Omics” technologies have …

Repurposing of Fluvastatin against Candida albicans CYP450 lanosterol 14 α-demethylase, a target enzyme for antifungal therapy: an In silico and In vitro study

R Rana, R Sharma, A Kumar - Current molecular medicine, 2019 - ingentaconnect.com
Background: The incidence of fungal infections has increased significantly. Specifically the
cases of candida albicans infection are increasing day by day and their resistance to …

Insights into the pivotal role of statins and its nanoformulations in hyperlipidemia

S Singh, I Zahoor, N Sharma, T Behl, N Kanojia… - … Science and Pollution …, 2022 - Springer
Hyperlipidemia is the primary cause of heart disorders and has been manifested as the
condition with remarkable higher levels of very-low-density lipoproteins, low-density …

Tamoxifen twists again: On and off-targets in macrophages and infections

C Sfogliarini, G Pepe, A Dolce, S Della Torre… - Frontiers in …, 2022 - frontiersin.org
Beyond the wide use of tamoxifen in breast cancer chemotherapy due to its estrogen
receptor antagonist activity, this drug is being assayed in repurposing strategies against a …

Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19

HAS Almosawey, FHO AL-Khikani… - Biomedical and …, 2020 - journals.lww.com
Tamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor
modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to …