Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …

Abstract Purpose of Review To examine the epidemiological data on obesity and leukemia;
evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic …

All vertebrate blood cells descend from multipotent hematopoietic stem cells (HSCs), whose
activity and differentiation depend on a complex and incompletely understood relationship …

Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been
administered to humans. However, we lack a comprehensive understanding of the immune …

Chronic viral infections are associated with hematopoietic suppression, bone marrow (BM)
failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral …

Stem cells show intrinsic interferon signalling, which protects them from viral infections at all
ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to …

Antibiotic therapy, especially when administered long term, is associated with adverse
hematologic effects such as cytopenia. Signals from the intestinal microbiota are critical to …

Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV
infection contributes to haematological abnormalities observed in HIV patients. The bone …

Patients with Down syndrome (DS), or trisomy 21 (T21), are at increased risk of transient
abnormal myelopoiesis (TAM) and acute megakaryoblastic leukemia (ML-DS). Both TAM …

Macrophages maintain hematopoietic stem cell (HSC) quality by assessing cell surface
Calreticulin (Calr), an “eat-me” signal induced by reactive oxygen species (ROS). Using …