Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
[HTML][HTML] Immunotherapies for aging-related neurodegenerative diseases—emerging perspectives and new targets
Neurological disorders such as Alzheimer's disease (AD), Lewy body dementia (LBD),
frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying …
frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying …
Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease
Introduction It is unclear how different proteinopathies (tau, transactive response DNA‐
binding protein 43 [TDP‐43], amyloid β [Aβ], and α‐synuclein) contribute to atrophy within …
binding protein 43 [TDP‐43], amyloid β [Aβ], and α‐synuclein) contribute to atrophy within …
Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration
Over the past decade, the transactive response DNA-binding protein of 43 kDa (TDP-43)
has been recognized as a major protein in normal and pathological ageing, increasing the …
has been recognized as a major protein in normal and pathological ageing, increasing the …
Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum
AE Denning, R Ittyerah, LM Levorse… - Acta …, 2024 - Springer
The medial temporal lobe (MTL) is a hotspot for neuropathology, and measurements of MTL
atrophy are often used as a biomarker for cognitive decline associated with …
atrophy are often used as a biomarker for cognitive decline associated with …
Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons
Objective To investigate the contribution of Alzheimer disease (AD) vs non-AD
neuropathologies to hippocampal atrophy. Methods The Religious Orders Study and Rush …
neuropathologies to hippocampal atrophy. Methods The Religious Orders Study and Rush …
Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome
Several studies have investigated the differential vulnerability of hippocampal subfields
during aging and Alzheimer's disease (AD). Results were often contradictory, mainly …
during aging and Alzheimer's disease (AD). Results were often contradictory, mainly …
Neuroprotective effect of quercetin through targeting key genes involved in aluminum chloride induced Alzheimer's disease in rats
HA Elreedy, AM Elfiky, AA Mahmoud… - Egyptian Journal of …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a neurodegenerative disorder that is clinically characterized by
deteriorating cognitive function. Quercetin (Q), a bioflavonoid, has been reported to slow …
deteriorating cognitive function. Quercetin (Q), a bioflavonoid, has been reported to slow …
[PDF][PDF] The unique effect of TDP-43 on hippocampal subfield morphometry and cognition
The relationship between neuropathologic disease and behavior is complex and poorly
understood. It is well known that similar disease processes can present in a variety of clinical …
understood. It is well known that similar disease processes can present in a variety of clinical …
Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia
Background Dementia patients commonly present multiple neuropathologies, worsening
cognitive function, yet structural neuroimaging signatures of dementia have not been …
cognitive function, yet structural neuroimaging signatures of dementia have not been …