Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Epidemiological studies have clearly shown that whole-grain cereals can protect against
obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety …

Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Auxin is a pivotal plant hormone that controls many aspects of plant growth and
development. Perceived by a small family of F-box proteins including transport inhibitor …

Noise, or random fluctuations, in gene expression may produce variability in cellular
behavior. To measure the noise intrinsic to eukaryotic gene expression, we quantified the …

Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate
gene expression by removing acetyl groups from lysine residues in histone tails, resulting in …

Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome
stability and cell survival. Homologous recombination provides an efficient and faithful …

In the eukaryotic genome, the thousands of genes that encode messenger RNA are
transcribed by a molecular machine called RNA polymerase II. Analysing the distribution …