The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer
upon hydration; liposome drug delivery systems have played a significant role in formulation …

During recent decades there have been remarkable advances in biology, in which one of
the most important discoveries is RNA interference (RNAi). RNAi is a specific post …

The phytochemical resveratrol, which is found in grapes and wine, has been reported to
have a variety of anti-inflammatory, anti-platelet, and anti-carcinogenic effects. Based on its …

The application of cationic liposome reagents has advanced DNA and mRNA transfection
research in vitro, and data are accumulating which show their utility for in vivo gene transfer …

To understand how DNA is released from cationic liposome/DNA complexes in cells, we
investigated which biomolecules mediate release of DNA from a complex with cationic …

Glycogen synthase kinase-3 (GSK-3), a protein-serine kinase implicated in cell-fate
determination and differentiation, phosphorylates several regulatory proteins that are …

A novel cationic derivative of cholesterol, 3β [N-(N′, N′-dimethylaminoethane)-carbamoyl]
cholesterol (DC-Chol), has been synthesized and used to prepare sonicated liposomes with …

We propose a mechanism for oligonucleotide (ODN) release from cationic lipid complexes
in cells that accounts for various observations on cationic lipid-nucleic acid-cell interactions …

The role of human dynamin in receptormediated endocytosis was investigated by transient
expression of GTP-binding domain mutants in mammalian cells. Using assays which detect …

Vaccinia virus, no longer required for immunization against smallpox, now serves as a
unique vector for expressing genes within the cytoplasm of mammalian cells. As a research …