The dark proteome: translation from noncanonical open reading frames

BW Wright, Z Yi, JS Weissman, J Chen - Trends in cell biology, 2022 - cell.com
Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …

Use of immunotherapy in the treatment of gastric cancer

L Yang, Y Wang, H Wang - Oncology letters, 2019 - spandidos-publications.com
Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which
typically presents in the advanced stages of disease in the majority of patients. Despite the …

Small proteins encoded by unannotated ORFs are rising stars of the proteome, confirming shortcomings in genome annotations and current vision of an mRNA

V Delcourt, A Staskevicius, M Salzet, I Fournier… - …, 2018 - Wiley Online Library
Short ORF‐encoded peptides and small proteins in eukaryotes have been hiding in the
shadow of large proteins for a long time. Recently, improved identifications in MS‐based …

[HTML][HTML] Identification of promiscuous African swine fever virus T-cell determinants using a multiple technical approach

L Bosch-Camós, E López, MJ Navas, S Pina-Pedrero… - Vaccines, 2021 - mdpi.com
The development of subunit vaccines against African swine fever (ASF) is mainly hindered
by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in …

Food-grade titanium dioxide (E171) induces anxiety, adenomas in colon and goblet cells hyperplasia in a regular diet model and microvesicular steatosis in a high fat …

EI Medina-Reyes, NL Delgado-Buenrostro… - Food and Chemical …, 2020 - Elsevier
Food-grade titanium dioxide (E171) is a white additive widely used in solid and liquid food
products. There is still debate about E171 toxic effects after oral consumption since this …

Spatial proteomics of human diabetic kidney disease, from health to class III

A Kondo, M McGrady, D Nallapothula, H Ali… - Diabetologia, 2024 - Springer
Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of chronic and end-
stage kidney disease in the USA and worldwide. Animal models have taught us much about …

Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene

M Gagnon, M Savard, JF Jacques, G Bkaily… - Journal of Biological …, 2021 - jbc.org
Recent functional and proteomic studies in eukaryotes (www. openprot. org) predict the
translation of alternative open reading frames (AltORFs) in mature G-protein-coupled …

In vivo anti-MUC1+ tumor activity and sequences of high-affinity anti-MUC1-SEA antibodies

E Pichinuk, M Chalik, I Benhar, R Ginat-Koton… - Cancer Immunology …, 2020 - Springer
Cleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit
bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed …

The alternative proteome in neurobiology

P Mohaupt, X Roucou, C Delaby, J Vialaret… - Frontiers in Cellular …, 2022 - frontiersin.org
Translation involves the biosynthesis of a protein sequence following the decoding of the
genetic information embedded in a messenger RNA (mRNA). Typically, the eukaryotic …

Deciphering the transcriptome of prepubertal buffalo mammary glands using RNA sequencing

RK Choudhary, S Choudhary… - Functional & integrative …, 2019 - Springer
Although water buffaloes are the main milk-producing animals in Indian subcontinent, only
limited attempts have been made to identify canonical pathways and gene regulatory …