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The dark proteome: translation from noncanonical open reading frames
Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …
the genome. In particular, these studies revealed widespread unannotated open reading …
Use of immunotherapy in the treatment of gastric cancer
L Yang, Y Wang, H Wang - Oncology letters, 2019 - spandidos-publications.com
Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which
typically presents in the advanced stages of disease in the majority of patients. Despite the …
typically presents in the advanced stages of disease in the majority of patients. Despite the …
Small proteins encoded by unannotated ORFs are rising stars of the proteome, confirming shortcomings in genome annotations and current vision of an mRNA
Short ORF‐encoded peptides and small proteins in eukaryotes have been hiding in the
shadow of large proteins for a long time. Recently, improved identifications in MS‐based …
shadow of large proteins for a long time. Recently, improved identifications in MS‐based …
[HTML][HTML] Identification of promiscuous African swine fever virus T-cell determinants using a multiple technical approach
The development of subunit vaccines against African swine fever (ASF) is mainly hindered
by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in …
by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in …
Food-grade titanium dioxide (E171) induces anxiety, adenomas in colon and goblet cells hyperplasia in a regular diet model and microvesicular steatosis in a high fat …
EI Medina-Reyes, NL Delgado-Buenrostro… - Food and Chemical …, 2020 - Elsevier
Food-grade titanium dioxide (E171) is a white additive widely used in solid and liquid food
products. There is still debate about E171 toxic effects after oral consumption since this …
products. There is still debate about E171 toxic effects after oral consumption since this …
Spatial proteomics of human diabetic kidney disease, from health to class III
A Kondo, M McGrady, D Nallapothula, H Ali… - Diabetologia, 2024 - Springer
Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of chronic and end-
stage kidney disease in the USA and worldwide. Animal models have taught us much about …
stage kidney disease in the USA and worldwide. Animal models have taught us much about …
Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene
M Gagnon, M Savard, JF Jacques, G Bkaily… - Journal of Biological …, 2021 - jbc.org
Recent functional and proteomic studies in eukaryotes (www. openprot. org) predict the
translation of alternative open reading frames (AltORFs) in mature G-protein-coupled …
translation of alternative open reading frames (AltORFs) in mature G-protein-coupled …
In vivo anti-MUC1+ tumor activity and sequences of high-affinity anti-MUC1-SEA antibodies
E Pichinuk, M Chalik, I Benhar, R Ginat-Koton… - Cancer Immunology …, 2020 - Springer
Cleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit
bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed …
bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed …
The alternative proteome in neurobiology
Translation involves the biosynthesis of a protein sequence following the decoding of the
genetic information embedded in a messenger RNA (mRNA). Typically, the eukaryotic …
genetic information embedded in a messenger RNA (mRNA). Typically, the eukaryotic …
Deciphering the transcriptome of prepubertal buffalo mammary glands using RNA sequencing
Although water buffaloes are the main milk-producing animals in Indian subcontinent, only
limited attempts have been made to identify canonical pathways and gene regulatory …
limited attempts have been made to identify canonical pathways and gene regulatory …