Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans.
In the process of purine metabolism, reactive oxygen species, including superoxide, are …

Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …

Background: Statins have long been used for the protection against coronary artery disease
(CAD). Their beneficial effect apart from cholesterol reduction lies in their pleiotropic …

Ample evidence exists in support of the potent anti-inflammatory properties of statins. In cell
studies and animal models statins exert beneficial cardiovascular effects. By inhibiting …

Chronic heart failure (CHF) is a complex syndrome that results from structural and functional
disturbances that affect the ability of the heart to supply oxygen to tissues. It largely affects …

Endothelial dysfunction has been associated with the development of atherosclerosis and
cardiovascular diseases. Adult endothelial progenitor cells (EPCs) are derived from …

Endothelial senescence is thought to play a role in CAD (coronary artery disease). miR-34a
(microRNA-34a) and other SIRT1 (silent information regulator 1)-related miRs have recently …

Heart failure is a complex medical syndrome that is attributed to a number of risk factors;
nevertheless, its clinical presentation is quite similar among the different etiologies. Heart …

Chronic kidney disease (CKD) is strongly associated with cardiovascular disease (CVD); a
graded inverse relationship between estimated glomerular filtration rate (eGFR) and …

Objective: Endothelial function is an independent predictor of prognosis in heart failure (HF)
subjects. Statins, beyond their lipid lowering role, exert beneficial effect in patients with …