Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair

Z Nikitaki, A Velalopoulou, V Zanni, I Tremi… - Expert reviews in …, 2022 - cambridge.org
DNA damage and repair studies are at the core of the radiation biology field and represent
also the fundamental principles informing radiation therapy (RT). DNA damage levels are a …

[HTML][HTML] Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

PE Postmus, KM Kerr, M Oudkerk, S Senan… - Annals of oncology, 2017 - Elsevier
Lung cancer is the leading cause of cancer mortality worldwide with 1.8 million newly
diagnosed cases, or 13% of all cancers diagnosed, in 2012 [1]. The worldwide numbers are …

Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating …

A Chi, H Chen, S Wen, H Yan, Z Liao - Radiotherapy and Oncology, 2017 - Elsevier
Purpose To assess hypo-fractionated particle beam therapy (PBT)'s efficacy relative to that
of photon stereotactic body radiotherapy (SBRT) for early stage (ES) non-small cell lung …

7‐year follow‐up after stereotactic ablative radiotherapy for patients with stage I non–small cell lung cancer: Results of a phase 2 clinical trial

B Sun, ED Brooks, RU Komaki, Z Liao, MD Jeter… - Cancer, 2017 - Wiley Online Library
BACKGROUND The authors evaluated the efficacy, patterns of failure, and toxicity of
stereotactic ablative radiotherapy (SABR) for patients with medically inoperable, clinical …

Individualized stereotactic ablative radiotherapy for lung tumors: the iSABR phase 2 nonrandomized controlled trial

MF Gensheimer, H Gee, H Shirato, H Taguchi… - JAMA …, 2023 - jamanetwork.com
Importance Stereotactic ablative radiotherapy (SABR) is used for treating lung tumors but
can cause toxic effects, including life-threatening damage to central structures …

[HTML][HTML] Risk of second lung cancer in patients with previously treated lung cancer: analysis of surveillance, epidemiology, and end results (SEER) data

MK Thakur, JJ Ruterbusch, AG Schwartz… - Journal of Thoracic …, 2018 - Elsevier
Introduction The risk for development of a second primary lung cancer (SPLC) after
treatment of an initial primary lung cancer (IPLC) is around 1% to 2% per patient per year …

Stereotactic body radiation therapy (SBRT) improves local control and overall survival compared to conventionally fractionated radiation for stage I non-small cell lung …

D von Reibnitz, F Shaikh, AJ Wu, GC Treharne… - Acta …, 2018 - Taylor & Francis
Background: Stereotactic body radiotherapy (SBRT) has been adopted as the standard of
care for inoperable early-stage non-small cell lung cancer (NSCLC), with local control rates …

Imaging features from pretreatment CT scans are associated with clinical outcomes in nonsmall‐cell lung cancer patients treated with stereotactic body radiotherapy

Q Li, J Kim, Y Balagurunathan, Y Liu, K Latifi… - Medical …, 2017 - Wiley Online Library
Purpose To investigate whether imaging features from pretreatment planning CT scans are
associated with overall survival (OS), recurrence‐free survival (RFS), and loco‐regional …

Oncologic outcomes of surgery versus SBRT for non–small-cell lung carcinoma: a systematic review and meta-analysis

MA Ijsseldijk, M Shoni, C Siegert, B Wiering… - Clinical Lung Cancer, 2021 - Elsevier
Background The optimal treatment of stage I non–small-cell lung carcinoma is subject to
debate. The aim of this study was to compare overall survival and oncologic outcomes of …

[HTML][HTML] ctDNA-based detection of molecular residual disease in stage I-III non-small cell lung cancer patients treated with definitive radiotherapy

ES Lebow, N Shaverdian, JE Eichholz… - Frontiers in …, 2023 - frontiersin.org
Background Sensitive and reliable biomarkers for early detection of recurrence are needed
to improve post-definitive radiation risk stratification, disease management, and outcomes …