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Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair
DNA damage and repair studies are at the core of the radiation biology field and represent
also the fundamental principles informing radiation therapy (RT). DNA damage levels are a …
also the fundamental principles informing radiation therapy (RT). DNA damage levels are a …
[HTML][HTML] Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Lung cancer is the leading cause of cancer mortality worldwide with 1.8 million newly
diagnosed cases, or 13% of all cancers diagnosed, in 2012 [1]. The worldwide numbers are …
diagnosed cases, or 13% of all cancers diagnosed, in 2012 [1]. The worldwide numbers are …
Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating …
A Chi, H Chen, S Wen, H Yan, Z Liao - Radiotherapy and Oncology, 2017 - Elsevier
Purpose To assess hypo-fractionated particle beam therapy (PBT)'s efficacy relative to that
of photon stereotactic body radiotherapy (SBRT) for early stage (ES) non-small cell lung …
of photon stereotactic body radiotherapy (SBRT) for early stage (ES) non-small cell lung …
7‐year follow‐up after stereotactic ablative radiotherapy for patients with stage I non–small cell lung cancer: Results of a phase 2 clinical trial
B Sun, ED Brooks, RU Komaki, Z Liao, MD Jeter… - Cancer, 2017 - Wiley Online Library
BACKGROUND The authors evaluated the efficacy, patterns of failure, and toxicity of
stereotactic ablative radiotherapy (SABR) for patients with medically inoperable, clinical …
stereotactic ablative radiotherapy (SABR) for patients with medically inoperable, clinical …
Individualized stereotactic ablative radiotherapy for lung tumors: the iSABR phase 2 nonrandomized controlled trial
Importance Stereotactic ablative radiotherapy (SABR) is used for treating lung tumors but
can cause toxic effects, including life-threatening damage to central structures …
can cause toxic effects, including life-threatening damage to central structures …
[HTML][HTML] Risk of second lung cancer in patients with previously treated lung cancer: analysis of surveillance, epidemiology, and end results (SEER) data
MK Thakur, JJ Ruterbusch, AG Schwartz… - Journal of Thoracic …, 2018 - Elsevier
Introduction The risk for development of a second primary lung cancer (SPLC) after
treatment of an initial primary lung cancer (IPLC) is around 1% to 2% per patient per year …
treatment of an initial primary lung cancer (IPLC) is around 1% to 2% per patient per year …
Stereotactic body radiation therapy (SBRT) improves local control and overall survival compared to conventionally fractionated radiation for stage I non-small cell lung …
D von Reibnitz, F Shaikh, AJ Wu, GC Treharne… - Acta …, 2018 - Taylor & Francis
Background: Stereotactic body radiotherapy (SBRT) has been adopted as the standard of
care for inoperable early-stage non-small cell lung cancer (NSCLC), with local control rates …
care for inoperable early-stage non-small cell lung cancer (NSCLC), with local control rates …
Imaging features from pretreatment CT scans are associated with clinical outcomes in nonsmall‐cell lung cancer patients treated with stereotactic body radiotherapy
Q Li, J Kim, Y Balagurunathan, Y Liu, K Latifi… - Medical …, 2017 - Wiley Online Library
Purpose To investigate whether imaging features from pretreatment planning CT scans are
associated with overall survival (OS), recurrence‐free survival (RFS), and loco‐regional …
associated with overall survival (OS), recurrence‐free survival (RFS), and loco‐regional …
Oncologic outcomes of surgery versus SBRT for non–small-cell lung carcinoma: a systematic review and meta-analysis
MA Ijsseldijk, M Shoni, C Siegert, B Wiering… - Clinical Lung Cancer, 2021 - Elsevier
Background The optimal treatment of stage I non–small-cell lung carcinoma is subject to
debate. The aim of this study was to compare overall survival and oncologic outcomes of …
debate. The aim of this study was to compare overall survival and oncologic outcomes of …
[HTML][HTML] ctDNA-based detection of molecular residual disease in stage I-III non-small cell lung cancer patients treated with definitive radiotherapy
Background Sensitive and reliable biomarkers for early detection of recurrence are needed
to improve post-definitive radiation risk stratification, disease management, and outcomes …
to improve post-definitive radiation risk stratification, disease management, and outcomes …