Sphingolipids, universal components of biological membranes of all eukaryotic organisms,
from yeasts to mammals, in addition of playing a structural role, also play an important part of …

As post-mitotic cells with great energy demands, neurons depend upon the homeostatic and
waste-recycling functions provided by autophagy. In addition, autophagy also promotes …

Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes the
lysosomal enzyme glucocerebrosidase (GCase). The severe forms of GD are associated …

Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal
storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which …

Mutations in the GBA1 gene are the single most frequent genetic risk factor for Parkinson's
disease (PD). Neurodegenerative changes in GBA1-associated PD have been linked to the …

Gaucher disease, the most common lysosomal storage disease, is caused by a recessively
inherited deficiency in glucocerebrosidase and subsequent accumulation of toxic lipid …

The UDP-glucose ceramide glucosyltransferase (UGCG) is a key enzyme in the synthesis of
glycosylated sphingolipids, since this enzyme generates the precursor for all complex …

Glycosphingolipids (GSLs) play a role in insulin resistance and diabetes, but their role in
diabetic nephropathy (DN) has received limited attention. We used 9-and 17-wk-old …

Summary Glucosylceramides (GlcCer), glucose‐conjugated sphingolipids, are major
components of the endomembrane system and plasma membrane in most eukaryotic cells …

Evasive mechanisms triggered by the tyrosine kinase inhibitor sorafenib reduce its efficacy
in hepatocellular carcinoma (HCC) treatment. Drug-resistant cancer cells frequently exhibit …