Androgens have a complex role in the regulation of insulin sensitivity in the pathogenesis of
type 2 diabetes. In male subjects, a reduction in androgens increases the risk for insulin …

Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males.
Here, we summarize recent evidence derived from clinical trials and studies in preclinical …

Vascular endothelial growth factor B (VEGF-B) has been suggested to play a crucial role in
regulating whole-body glucose homeostasis. However, the involved mechanisms are not …

Simple Summary In this paper, we investigated the early-castrated Holstein cattle liver
transcriptome and metabolome and conducted a comprehensive analysis of two omics …

Castration is a common practice in beef cattle production systems to manage breeding and
enhance meat quality by promoting intramuscular fat (IMF) deposition, known as marbling …

Background Testosterone deficiency is linked to an increased prevalence of non-alcoholic
fatty liver disease (NAFLD), although the mechanisms underlying this association are not …

Gene mutations in the extracellular matrix protein fibrillin-1 cause connective tissue
disorders including Marfan syndrome (MFS) with clinical symptoms in the cardiovascular …

Low or insufficient testosterone levels caused by caponization promote fat deposition in
animals. However, the molecular mechanism of fat deposition in caponized animals remains …

Background & aims Testosterone, vital for reproductive health and muscle development,
declines with age, increasing susceptibility to conditions like diabetes, obesity and …

Sex steroids modify feeding behavior and body weight regulation, and androgen reportedly
augments food intake and body weight gain. To elucidate the role of endogenous …