A mechanism-based theory of cellular and tissue plasticity

F Sun, C Fang, X Shao, H Gao… - Proceedings of the …, 2023 - National Acad Sciences
Plastic deformation in cells and tissues has been found to play crucial roles in collective cell
migration, cancer metastasis, and morphogenesis. However, the fundamental question of …

Metal-ion-binding properties of glycyrrhiza polysaccharide extracted from Licorice: Structural characterization and potential application in drug delivery

Y Yang, M Yu, Y Mo, Y Cheng, B Huang, W Wang… - Carbohydrate …, 2024 - Elsevier
Licorice is not only a widely used food, but also a classic tonic Chinese medicine, which
mainly contains glycyrrhiza polysaccharides (GP) and flavonoids with excellent anti …

Mechanical Stimulation of Anti‐Inflammatory and Antioxidant Hydrogels for Rapid Re‐Epithelialization

W Yang, W Zhong, S Yan, S Wang, C Xuan… - Advanced …, 2024 - Wiley Online Library
The epithelium, an essential barrier to protect organisms against infection, exists in many
organs. However, rapid re‐epithelialization to restore tissue integrity and function in an …

Drug-free and multifunctional sodium bicarbonate/hyaluronic acid hybrid dressing for synergistic healing of infected wounds

Y Li, H Li, Z Yu, J Liu, Y Lin, J Xu, C Zhang… - International Journal of …, 2024 - Elsevier
Skin wounds are susceptible to microbial infections which commonly lead to the delayed
wound healing. Rapid clearance of pathogens from the wound is of great significance and …

The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression

A Akinpelu, T Akinsipe, LA Avila, RD Arnold… - Cancer and Metastasis …, 2024 - Springer
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the
contribution of genetic and epigenetic modifications to breast cancer progression has been …

Tuning extracellular fluid viscosity to enhance transfection efficiency

J Ma, Y Zhu, J Kong, D Yu, WH Toh, M Jain… - Nature Chemical …, 2024 - nature.com
Gene therapies and cellular programming rely on effective cell transfection. Despite
continuous advancements in carrier development and transfection techniques to enhance …

Hydrogen, bicarbonate, and their associated exchangers in cell volume regulation

Y Li, X Zhou, SX Sun - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cells lacking a stiff cell wall, eg, mammalian cells, must actively regulate their volume to
maintain proper cell function. On the time scale that protein production is negligible, water …

[HTML][HTML] Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

Q Ni, Z Ge, Y Li, G Shatkin, J Fu, A Sen, K Bera, Y Yang… - Cell Reports, 2024 - cell.com
Mammalian cells rapidly respond to environmental changes by altering transmembrane
water and ion fluxes, changing cell volume. Contractile forces generated by actomyosin …

Profiling migration of human monocytes in response to chemotactic and barotactic guidance cues

CK Hall, OM Barr, A Delamare, A Burkholder, A Tsai… - Cell Reports …, 2024 - cell.com
Monocytes are critical to innate immunity, participating in chemotaxis during tissue injury,
infection, and inflammatory conditions. However, the migration dynamics of human …

Confinement controls the directional cell responses to fluid forces

F Amiri, AA Akinpelu, WC Keith, F Hemmati… - Cell reports, 2024 - cell.com
Our understanding of how fluid forces influence cell migration in confining environments
remains limited. By integrating microfluidics with live-cell imaging, we demonstrate that cells …