Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Conditioned medium–is it an undervalued lab waste with the potential for osteoarthritis management?

MA Rosochowicz, MS Lach, M Richter… - Stem Cell Reviews and …, 2023 - Springer
Background The approaches currently used in osteoarthritis (OA) are mainly short-term
solutions with unsatisfactory outcomes. Cell-based therapies are still controversial (in terms …

Alginate/gelatin encapsulation promotes NK cells differentiation potential of bone marrow resident C-kit+ hematopoietic stem cells

E Fathi, R Farahzadi, B Valipour - International journal of biological …, 2021 - Elsevier
The ability of natural killer (NK) cells to destroy cancerous cells with no prior sensitization
has made them attractive candidates for cell therapy. The application of hydrogels must be …

[HTML][HTML] Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

K Adibkia, A Ehsani, A Jodaei, E Fathi… - Beilstein journal of …, 2021 - beilstein-journals.org
Finding new strategies for the treatment of heart failures using stem cells has attracted a lot
of attention. Meanwhile, nanotechnology-based approaches to regenerative medicine …

[HTML][HTML] 3D-MSCs A151 ODN-loaded exosomes are immunomodulatory and reveal a proteomic cargo that sustains wound resolution

SP Camões, O Bulut, V Yazar, MM Gaspar… - Journal of Advanced …, 2022 - Elsevier
Introduction Non-healing wounds remain a major burden due to the lack of effective
treatments. Mesenchymal stem cell-derived exosomes (MSC-Exo) have emerged as …

Mesenchymal stem cells promote caspase-3 expression of SH-SY5Y neuroblastoma cells via reducing telomerase activity and telomere length

E Fathi, S Vandghanooni… - Iranian journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Objective (s): The use of mesenchymal stem cells in malignancies has attracted much
attention due to their ability to deliver anticancer agents to tumors, including cytokines …

Synthesis and in vitro evaluation of thermosensitive hydrogel scaffolds based on (PNIPAAm-PCL-PEG-PCL-PNIPAAm)/Gelatin and (PCL-PEG-PCL)/Gelatin for use in …

S Saghebasl, S Davaran, R Rahbarghazi… - Journal of …, 2018 - Taylor & Francis
Background: Biodegradable thermosensitive hydrogel scaffolds based on novel three-block
PCL-PEG-PCL and penta block PNIPAAm-PCL-PEG-PCL-PNIPAAm copolymers blended …

[HTML][HTML] Application of advanced nanomaterials for kidney failure treatment and regeneration

A Eftekhari, S Maleki Dizaj, E Ahmadian, A Przekora… - Materials, 2021 - mdpi.com
The implementation of nanomedicine not only provides enhanced drug solubility and
reduced off-target adverse effects, but also offers novel theranostic approaches in clinical …

Polymeric hydrogels as mesenchymal stem cell secretome delivery system in biomedical applications

M Arifka, G Wilar, KM Elamin, N Wathoni - Polymers, 2022 - mdpi.com
Secretomes of mesenchymal stem cells (MSCs) have been successfully studied in
preclinical models for several biomedical applications, including tissue engineering, drug …

[HTML][HTML] Umbilical cord MSCs and their secretome in the therapy of arthritic diseases: a research and industrial perspective

C Arrigoni, D D'Arrigo, V Rossella, C Candrian… - Cells, 2020 - mdpi.com
The prevalence of arthritic diseases is increasing in developed countries, but effective
treatments are currently lacking. The injection of mesenchymal stem cells (MSCs) represents …