Traditional treatments such as chemotherapy and surgery usually cause severe side effects
and excruciating pain. The emergence of nanomedicines and minimally invasive therapies …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

Genes showing higher expression in either tumor or metastatic tissues can help in better
understanding tumor formation and can serve as biomarkers of progression or as potential …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …

Background The rapid development of single-cell RNA-sequencing (scRNA-seq)
technologies has led to the emergence of many methods for removing systematic technical …

Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In
human cancers that are accessible for O 2 electrode measurements, intratumoral hypoxia is …

Abstract Tumor-associated macrophages (TAMs), as a major and essential component of
tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) …

Although several early phase clinical trials raised enthusiasm for the use of insulin-like
growth factor I receptor (IGF1R)-specific antibodies for cancer treatment, initial Phase III …

It is expected that emerging digital gene expression (DGE) technologies will overtake
microarray technologies in the near future for many functional genomics applications. One of …