Computational methods for discovering gene networks from expression data

WP Lee, WS Tzou - Briefings in bioinformatics, 2009 - academic.oup.com
Designing and conducting experiments are routine practices for modern biologists. The real
challenge, especially in the post-genome era, usually comes not from acquiring data, but …

Extended local similarity analysis (eLSA) of microbial community and other time series data with replicates

LC **a, JA Steele, JA Cram, ZG Cardon… - BMC systems …, 2011 - Springer
Background The increasing availability of time series microbial community data from
metagenomics and other molecular biological studies has enabled the analysis of large …

TimeDelay-ARACNE: Reverse engineering of gene networks from time-course data by an information theoretic approach

P Zoppoli, S Morganella, M Ceccarelli - BMC bioinformatics, 2010 - Springer
Background One of main aims of Molecular Biology is the gain of knowledge about how
molecular components interact each other and to understand gene function regulations …

Identifying local associations in biological time series: algorithms, statistical significance, and applications

D Ai, L Chen, J **e, L Cheng, F Zhang… - Briefings in …, 2023 - academic.oup.com
Local associations refer to spatial–temporal correlations that emerge from the biological
realm, such as time-dependent gene co-expression or seasonal interactions between …

The G-Box transcriptional regulatory code in Arabidopsis

D Ezer, SJK Shepherd, A Brestovitsky… - Plant …, 2017 - academic.oup.com
Plants have significantly more transcription factor (TF) families than animals and fungi, and
plant TF families tend to contain more genes; these expansions are linked to adaptation to …

Grouped graphical Granger modeling for gene expression regulatory networks discovery

AC Lozano, N Abe, Y Liu, S Rosset - Bioinformatics, 2009 - academic.oup.com
We consider the problem of discovering gene regulatory networks from time-series
microarray data. Recently, graphical Granger modeling has gained considerable attention …

Causality and pathway search in microarray time series experiment

ND Mukhopadhyay, S Chatterjee - Bioinformatics, 2007 - academic.oup.com
Motivation: Interaction among time series can be explored in many ways. All the approach
has the usual problem of low power and high dimensional model. Here we attempted to …

Large-scale dynamic gene regulatory network inference combining differential equation models with local dynamic Bayesian network analysis

Z Li, P Li, A Krishnan, J Liu - Bioinformatics, 2011 - academic.oup.com
Motivation: Reverse engineering gene regulatory networks, especially large size networks
from time series gene expression data, remain a challenge to the systems biology …

[PDF][PDF] Temporal boolean network models of genetic networks and their inference from gene expression time series

A Silvescu, V Honavar - Complex systems, 2001 - content.wolfram.com
Identification of genetic regulatory networks and genetic signal transduction pathways from
gene expression data is one of the key problems in computational molecular biology …

Discretization of gene expression data revised

CA Gallo, RL Cecchini, JA Carballido… - Briefings in …, 2016 - academic.oup.com
Gene expression measurements represent the most important source of biological data
used to unveil the interaction and functionality of genes. In this regard, several data mining …