Updated management of acute severe ulcerative colitis: From steroids to novel medical strategies

L Calméjane, D Laharie, J Kirchgesner… - United European …, 2023 - Wiley Online Library
Acute severe ulcerative colitis (ASUC) occurs in up to 25% of patients with ulcerative colitis
(UC). Therapeutic approaches have evolved during the past years with the increasing bio …

[HTML][HTML] Predicting outcome after acute severe ulcerative colitis: A contemporary review and areas for future research

SK Vuyyuru, OM Nardone, V Jairath - Journal of Clinical Medicine, 2024 - mdpi.com
Acute Severe Ulcerative Colitis (ASUC) is a severe form of ulcerative colitis relapse which
requires hospitalization and intensive medical intervention to avoid colectomy. The timely …

Tofacitinib in Acute Severe Ulcerative Colitis (TACOS): a randomized controlled trial

A Singh, MK Goyal, V Midha, R Mahajan… - Official journal of the …, 2024 - journals.lww.com
METHODS: This single-center, double-blind, placebo-controlled trial randomized adult
patients with ASUC (defined by the Truelove Witts severity criteria) to receive either …

Acute severe ulcerative colitis management: unanswered questions and latest insights

P Rivière, CLW Suen, M Chaparro… - The Lancet …, 2024 - thelancet.com
Acute severe ulcerative colitis (ASUC) is a distinctive ulcerative colitis flare presentation
characterised by the presence of systemic inflammation as well as bloody diarrhoea, and …

Indeterminate colitis–update on treatment options

N Venkateswaran, S Weismiller… - Journal of Inflammation …, 2021 - Taylor & Francis
Indeterminate colitis (IC) is described in approximately 5–15% of patients with inflammatory
bowel disease (IBD). It usually reflects a difficulty or lack of clarity in distinguishing between …

Long-term risk of colectomy in patients with severe ulcerative colitis responding to intravenous corticosteroids or infliximab

E De Cristofaro, S Salvatori, I Marafini, F Zorzi… - Journal of Clinical …, 2022 - mdpi.com
Background and aims: Intravenous corticosteroids (IVCS) and rescue therapy with infliximab
(IFX) are useful for managing patients with acute severe ulcerative colitis (ASUC). However …

[HTML][HTML] Cyclosporine therapy as a rescue treatment in steroid refractory acute severe ulcerative colitis: a real life data from a tertiary center

S Evirgen, R İliaz, F Akyüz, B Çavuş… - The Turkish Journal …, 2022 - ncbi.nlm.nih.gov
Background: Cyclosporine is a rescue treatment alternative to avoid colectomy in
corticosteroid refractory acute severe ulcerative colitis. In this study, we aimed to evaluate …

Optimal management of acute severe ulcerative colitis (ASUC): challenges and solutions

T Holvoet, T Lobaton, P Hindryckx - Clinical and experimental …, 2021 - Taylor & Francis
Acute severe colitis is a severe complication of ulcerative colitis, affecting approximately
20% of patients. For physicians, it remains a challenging condition to treat. Current treatment …

Have changing practices in salvage medical options affected colectomy rates in acute severe ulcerative colitis?

N Clark, M MacIsaac, R Little, S Vogrin… - Internal Medicine …, 2023 - Wiley Online Library
Abstract Background In 2014, infliximab (IFX) was listed on the Australian Pharmaceutical
Benefits Scheme for acute severe ulcerative colitis (ASUC) and is now the preferred option …

[HTML][HTML] Recent Advances in the Management of Acute Severe Ulcerative Colitis

EOM San, K Sharif, K Rosiou… - Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
Acute severe ulcerative colitis is a medical emergency requiring inpatient treatment with
intravenous steroids. Approximately one-third of patients do not respond to steroids …