The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Agarose is a natural polysaccharide polymer having unique characteristics that give reason
to consider it for tissue engineering applications. Special characteristics of agarose such as …

Despite tremendous advances in the field of regenerative medicine, it still remains
challenging to repair the osteochondral interface and full-thickness articular cartilage …

The encapsulation of living mammalian cells within a semi-permeable hydrogel matrix is an
attractive procedure for many biomedical and biotechnological applications, such as …

Bioprinting is rapidly being adopted as a major method for fabricating tissue engineering
constructs. Through the precise deposition of cell-and bioactive molecule-laden materials …

The differentiation and growth of adult stem cells within engineered tissue constructs are
hypothesized to be influenced by cell-biomaterial interactions. In this study, we compared …

Articular cartilage has poor ability to heal once damaged. Tissue engineering with scaffolds
of polymer hydrogels is promising for cartilage regeneration and repair. Polymer hydrogels …

Mechanical loads induce changes in the structure, composition, and function of living
tissues. Cells in tissues are responsible for these changes, which cause physiological or …

The repair of articular cartilage defects remains a significant challenge in orthopedic
medicine. Hydrogels, three-dimensional polymer networks swollen in water, offer a unique …

BACKGROUND: The developmental history of the chondrocyte results in a cell whose
biosynthetic activities are optimized to maintain the concentration and organization of a …