Genomic epidemiology in filarial nematodes: transforming the basis for elimination program decisions

SM Hedtke, AC Kuesel, KE Crawford, PM Graves… - Frontiers in …, 2020 - frontiersin.org
Onchocerciasis and lymphatic filariasis are targeted for elimination, primarily using mass
drug administration at the country and community levels. Elimination of transmission is the …

Complex I and II subunit gene duplications provide increased fitness to worms

L Otero, C Martínez-Rosales, E Barrera… - Frontiers in …, 2019 - frontiersin.org
Helminths use an alternative mitochondrial electron transport chain (ETC) under hypoxic
conditions, such as those found in the gastrointestinal tract. In this alternative ETC, fumarate …

Utility of the Onchocerca volvulus mitochondrial genome for delineation of parasite transmission zones

KE Crawford, SM Hedtke, SR Doyle, AC Kuesel… - bioRxiv, 2019 - biorxiv.org
In 2012, the reduction in Onchocerca volvulus infection prevalence through long-term mass
ivermectin distribution in African meso-and hyperendemic areas motivated expanding …

Synthesising environmental, epidemiological, and genetic data to assist decision making for onchocerciasis elimination

H Shrestha, K McCulloch, RH Chisholm, S Armoo… - medRxiv, 2023 - medrxiv.org
Background Population genetics is crucial for understanding the transmission dynamics of
diseases like onchocerciasis. Landscape genetics identifies the ecological features that …

New tools for onchocerciasis elimination in Africa: the role of spatially explicit models in informing decisions

H Shrestha - 2023 - opal.latrobe.edu.au
New Tools for Onchocerciasis Elimination in Africa: the Role of Spatially Explicit Models in
Informing Decisions Page 1 New Tools for Onchocerciasis Elimination in Africa: the Role of …