Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest
common genetic risk factor for Parkinson's disease (PD), the second most common …

Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

Parkinson's disease belongs to a group of currently incurable neurodegenerative disorders
characterized by the misfolding and accumulation of alpha‐synuclein aggregates that are …

Extracellular vesicles (EVs, including exosomes) are implicated in many aspects of nervous
system development and function, including regulation of synaptic communication, synaptic …

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in
the cell. It plays a central role in determining the composition of the plasma membrane and …

Proteostasis is maintained by multiple cellular pathways, including protein synthesis, quality
control, and degradation. An imbalance of neuronal proteostasis, associated with protein …