Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Microglia respond to CNS injuries and diseases with complex reactions, often called
“activation.” A pro-inflammatory phenotype (also called classical or M1 activation) lies at one …

Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …

Normal cell-cycle progression is a crucial task for every multicellular organism, as it
determines body size and shape, tissue renewal and senescence, and is also crucial for …

Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …

Microglia are resident cells of the brain involved in regulatory processes critical for
development, maintenance of the neural environment, injury and repair. They belong to the …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

Although relatively neglected previously, research efforts in the past decade or so have
identified a pivotal role for glial cells in regulating neuronal function. Particular emphasis has …

Ion channels have emerged as regulators of developmental processes. In model organisms
and in people with mutations in ion channels, disruption of ion channel function can affect …