The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …

The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …

Most cells in the liver are polyploid, but the functional role of polyploidy is unknown.
Polyploidization occurs through cytokinesis failure and endoreduplication around the time of …

The NRF2 transcription factor controls a cell stress program that is implicated in cancer and
there is great interest in targeting NRF2 for therapy. We show that NRF2 activity depends on …

The liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid,
etc.) nuclear content. Polyploid hepatocytes are commonly found in adult mammals …

Simple Summary The efficacy of cancer therapeutics depends on several factors, including
the tumor genome, epigenome, and transcriptome. In addition, the tumor microenvironment …

Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic
mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a …

Abstract Development of breast cancer is linked to altered regulation of mammary gland
developmental processes. A better understanding of normal mammary gland development …

Orchestrating cell-cycle-dependent mRNA oscillations is critical to cell proliferation in
multicellular organisms. Even though our understanding of cell-cycle-regulated transcription …

Cell proliferation is tightly controlled by inhibitors that block cell cycle progression until
growth signals relieve this inhibition, allowing cells to divide. In several tissues, including the …