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A guide to single-particle tracking
Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …
Anomalous transport in the crowded world of biological cells
A ubiquitous observation in cell biology is that the diffusive motion of macromolecules and
organelles is anomalous, and a description simply based on the conventional diffusion …
organelles is anomalous, and a description simply based on the conventional diffusion …
Lipid rafts as a membrane-organizing principle
Cell membranes display a tremendous complexity of lipids and proteins designed to perform
the functions cells require. To coordinate these functions, the membrane is able to laterally …
the functions cells require. To coordinate these functions, the membrane is able to laterally …
Revitalizing membrane rafts: new tools and insights
Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …
Lipid rafts as major platforms for signaling regulation in cancer
Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …
The membrane surface as a platform that organizes cellular and biochemical processes
Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …
and organelles. In addition, their surfaces actively participate in biochemical reaction …
Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes
Membrane lipids and proteins are non-randomly distributed and are unable to diffuse freely
in the plane of the membrane. This is because of multiple constraints imposed both by the …
in the plane of the membrane. This is because of multiple constraints imposed both by the …
Lipid raft microdomains and neurotransmitter signalling
Lipid rafts are specialized structures on the plasma membrane that have an altered lipid
composition as well as links to the cytoskeleton. It has been proposed that these structures …
composition as well as links to the cytoskeleton. It has been proposed that these structures …
Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes
Although the highly dynamic and mosaic organization of the plasma membrane is well-
recognized, depicting a resolved, global view of this organization remains challenging. We …
recognized, depicting a resolved, global view of this organization remains challenging. We …
Dynamic organizing principles of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolson's fluid …
The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …
membrane has prompted major modifications of the textbook fluid-mosaic model. However …