The multifunctional role of herbal products in the management of diabetes and obesity: a comprehensive review

MM Rahman, MR Islam, S Shohag, ME Hossain… - Molecules, 2022 - mdpi.com
Obesity and diabetes are the most demanding health problems today, and their prevalence,
as well as comorbidities, is on the rise all over the world. As time goes on, both are …

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - portlandpress.com
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Five years of GWAS discovery

PM Visscher, MA Brown, MI McCarthy… - The American Journal of …, 2012 - cell.com
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …

The bigger picture of FTO—the first GWAS-identified obesity gene

RJF Loos, GSH Yeo - Nature Reviews Endocrinology, 2014 - nature.com
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

EK Speliotes, CJ Willer, SI Berndt, KL Monda… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

[HTML][HTML] Molecular genetics of human obesity: A comprehensive review

RK Singh, P Kumar, K Mahalingam - Comptes rendus biologies, 2017 - Elsevier
Obesity and its related health complications is a major problem worldwide. Hypothalamus
and their signalling molecules play a critical role in the intervening and coordination with …

Obesity and type 2 diabetes: what can be unified and what needs to be individualized?

RH Eckel, SE Kahn, E Ferrannini… - The Journal of …, 2011 - academic.oup.com
Objective: This report examines what is known about the relationship between obesity and
type 2 diabetes and how future research in these areas might be directed to benefit …

Genomics, type 2 diabetes, and obesity

MI McCarthy - New England Journal of Medicine, 2010 - Mass Medical Soc
Genomics, Type 2 Diabetes, and Obesity | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

JF Felix, JP Bradfield, C Monnereau… - Human molecular …, 2016 - academic.oup.com
A large number of genetic loci are associated with adult body mass index. However, the
genetics of childhood body mass index are largely unknown. We performed a meta-analysis …