Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

Bile formation is a fundamental physiological process that is vital to the survival of all
vertebrates. However, little was known about the mechanisms of this secretion until after …

Two common features of dietary polyphenols have hampered our mechanistic
understanding of their beneficial effects for decades: targeting multiple organs and …

Background Bile acids are important endocrine modulators of intestinal and hepatic
signalling cascades orchestrating critical pathophysiological processes in various liver …

Beyond their role as emulsifiers of lipophilic compounds, bile acids (BAs) are signaling
endocrine molecules that show differential affinity and specificity for a variety of canonical …

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

The prevalence of nonalcoholic steatohepatitis (NASH) is increasing rapidly worldwide, and
NASH has become a serious problem for human health. Recently, the selective activation of …

Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and
have been implicated in various disorders affecting the gut or liver. They may play a role …

Farnesoid X receptor (FXR) was considered as a promising drug target in the treatment of
cholestasis, drug-induced liver injury, and non-alcoholic steatohepatitis (NASH). However …