Molecular mechanisms of environmental exposures and human disease

H Wu, CM Eckhardt, AA Baccarelli - Nature reviews genetics, 2023 - nature.com
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Understanding health inequalities through the lens of social epigenetics

CL Martin, L Ghastine, EK Lodge… - Annual review of …, 2022 - annualreviews.org
Longstanding racial/ethnic inequalities in morbidity and mortality persist in the United States.
Although the determinants of health inequalities are complex, social and structural factors …

Objectives, design and main findings until 2020 from the Rotterdam Study

MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Lower socioeconomic status and the acceleration of aging: An outcome-wide analysis

A Steptoe, P Zaninotto - Proceedings of the National Academy of Sciences, 2020 - pnas.org
Aging involves decline in a range of functional abilities and phenotypes, many of which are
also associated with socioeconomic status (SES). Here we assessed whether lower SES is …

DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study

G Fiorito, S Caini, D Palli, B Bendinelli, C Saieva… - Aging cell, 2021 - Wiley Online Library
Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …

[HTML][HTML] What is new in the exposome?

P Vineis, O Robinson, M Chadeau-Hyam… - Environment …, 2020 - Elsevier
The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …

Determination of biological age: geriatric assessment vs biological biomarkers

LWM Diebel, K Rockwood - Current oncology reports, 2021 - Springer
Abstract Purpose of Review Biological age is the concept of using biophysiological
measures to more accurately determine an individual's age-related risk of adverse …

A pan-tissue DNA-methylation epigenetic clock based on deep learning

LP de Lima Camillo, LR Lapierre, R Singh - npj Aging, 2022 - nature.com
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …

Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

RF Hillary, AJ Stevenson, DL McCartney… - Clinical …, 2020 - Springer
Background Individuals of the same chronological age display different rates of biological
ageing. A number of measures of biological age have been proposed which harness age …

Socioeconomic disadvantage and the pace of biological aging in children

L Raffington, DW Belsky, M Kothari, M Malanchini… - …, 2021 - publications.aap.org
METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …