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Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
Understanding health inequalities through the lens of social epigenetics
Longstanding racial/ethnic inequalities in morbidity and mortality persist in the United States.
Although the determinants of health inequalities are complex, social and structural factors …
Although the determinants of health inequalities are complex, social and structural factors …
Objectives, design and main findings until 2020 from the Rotterdam Study
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …
Lower socioeconomic status and the acceleration of aging: An outcome-wide analysis
A Steptoe, P Zaninotto - Proceedings of the National Academy of Sciences, 2020 - pnas.org
Aging involves decline in a range of functional abilities and phenotypes, many of which are
also associated with socioeconomic status (SES). Here we assessed whether lower SES is …
also associated with socioeconomic status (SES). Here we assessed whether lower SES is …
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study
Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
[HTML][HTML] What is new in the exposome?
The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …
internal sources including chemical agents, biological agents, or radiation, from conception …
Determination of biological age: geriatric assessment vs biological biomarkers
Abstract Purpose of Review Biological age is the concept of using biophysiological
measures to more accurately determine an individual's age-related risk of adverse …
measures to more accurately determine an individual's age-related risk of adverse …
A pan-tissue DNA-methylation epigenetic clock based on deep learning
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …
created in recent years, with the vast majority based on regularized linear regression. This …
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Background Individuals of the same chronological age display different rates of biological
ageing. A number of measures of biological age have been proposed which harness age …
ageing. A number of measures of biological age have been proposed which harness age …
Socioeconomic disadvantage and the pace of biological aging in children
METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …