Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

In the modern world, cardiovascular disease is a leading cause of death for both men and
women. Epidemiologic studies consistently have suggested an association between low …

During aging, deterioration in cardiac structure and function leads to increased susceptibility
to heart failure. The need for interventions to combat this age-related cardiac decline is …

Aims Circular RNA (circRNA) is a newly validated class of single-stranded RNA,
ubiquitously expressed in mammalian tissues and possessing key functions including acting …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

Background Cardiovascular disease (CVD) is the leading cause of death worldwide and
considered one of the most environmentally driven diseases. The role of DNA methylation in …

The heart is a highly specialized organ with essential function for the organism throughout
life. The significance of DNA methylation in sha** the phenotype of the heart remains only …

Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby
eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and …

Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …

Advances in medical and device therapies have demonstrated the capacity of the heart to
reverse the failing phenotype. The development of normative changes to ventricular size …