DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …

Epigenetic regulation of gene expression is an increasingly well-understood concept that
explains much of the contribution of an organism's environment and experience to its …

The rate of transcription elongation plays an important role in the timing of expression of full-
length transcripts as well as in the regulation of alternative splicing. In this study, we coupled …

Abstract Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved
histone methyltransferase that methylates lysine 79 located within the globular domain of …

Within the vast landscape of histone modifications lysine methylation has gained increasing
attention because of its profound regulatory potential. The methylation of lysine residues on …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …

For more than three decades, investigators have sought to identify the precise locations
where DNA replication initiates in mammalian genomes. The development of molecular and …

Lysine methylation is an abundant posttranslational modification, which has been most
intensively studied in the context of histone proteins, where it represents an important …

Histone modifications regulate key processes of eukaryotic genomes. Misregulation of the
enzymes that place these modifications can lead to disease. An example of this is DOT1L …

Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates
diverse cellular processes, such as development, reprogramming, differentiation, and …