The role of the hippocampus in the consolidation of emotional memories during sleep

É Pronier, JF Morici, G Girardeau - Trends in Neurosciences, 2023 - cell.com
Episodic memory relies on the hippocampus, a heterogeneous brain region with distinct
functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for …

Tuned geometries of hippocampal representations meet the computational demands of social memory

LM Boyle, L Posani, S Irfan, SA Siegelbaum, S Fusi - Neuron, 2024 - cell.com
Social memory consists of two processes: the detection of familiar compared with novel
conspecifics and the detailed recollection of past social episodes. We investigated the …

The hippocampal horizon: Constructing and segmenting experience for episodic memory

TW Ross, A Easton - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
How do we recollect specific events that have occurred during continuous ongoing
experience? There is converging evidence from non-human animals that spatially …

Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal

S Krishnan, C Heer, C Cherian, MEJ Sheffield - Nature communications, 2022 - nature.com
Hippocampal place cells support reward-related spatial memories by forming a cognitive
map that over-represents reward locations. The strength of these memories is modulated by …

[HTML][HTML] Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats

W Wang, PJ Schuette, J Nagai, BC Tobias, FMCV Reis… - Neuron, 2021 - cell.com
Naturalistic escape requires versatile context-specific flight with rapid evaluation of local
geometry to identify and use efficient escape routes. It is unknown how spatial navigation …

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus

AM Barth, M Jelitai, MF Vasarhelyi-Nagy… - Nature …, 2023 - nature.com
Throughout life animals inevitably encounter unforeseen threatening events. Activity of
principal cells in the hippocampus is tuned for locations and for salient stimuli in the animals' …

The physical basis of memory

CR Gallistel - Cognition, 2021 - Elsevier
Neuroscientists are searching for the engram within the conceptual framework established
by John Locke's theory of mind. This framework was elaborated before the development of …

Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

W Wang, PJ Schuette, MQ La-Vu, A Torossian… - Elife, 2021 - elifesciences.org
Escape from threats has paramount importance for survival. However, it is unknown if a
single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin …

Shared dorsal periaqueductal gray activation patterns during exposure to innate and conditioned threats

FMCV Reis, J Liu, PJ Schuette, JY Lee… - Journal of …, 2021 - jneurosci.org
The brainstem dorsal periaqueductal gray (dPAG) has been widely recognized as being a
vital node orchestrating the responses to innate threats. Intriguingly, recent evidence also …

Dorsal periaqueductal gray ensembles represent approach and avoidance states

FMCV Reis, JY Lee, S Maesta-Pereira, PJ Schuette… - Elife, 2021 - elifesciences.org
Animals must balance needs to approach threats for risk assessment and to avoid danger.
The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how …