Endocytosis at the nanoscale

I Canton, G Battaglia - Chemical Society Reviews, 2012 - pubs.rsc.org
Endocytosis is a fundamental process in which eukaryotic cells internalise molecules and
macromolecules via deformation of the membrane and generation of membrane-bound …

Polymeric vesicles in biomedical applications

RP Brinkhuis, FPJT Rutjes, JCM van Hest - Polymer Chemistry, 2011 - pubs.rsc.org
Polymeric vesicles, or polymersomes, are nano-to micrometre sized polymeric capsules with
a bilayered membrane. Applications of these vesicles are foreseen in nanomedicine, in vivo …

Layer‐by‐layer‐assembled capsules and films for therapeutic delivery

AL Becker, APR Johnston, F Caruso - Small, 2010 - Wiley Online Library
Polymeric materials formed via layer‐by‐layer (LbL) assembly have promise for use as drug
delivery vehicles. These multilayered materials, both as capsules and thin films, can …

Beyond the lipid-bilayer: interaction of polymers and nanoparticles with membranes

M Schulz, A Olubummo, WH Binder - Soft Matter, 2012 - pubs.rsc.org
Membranes can be fabricated either from lipid or polymer molecules, leading to the
formation of liposomes or polymersomes. In all types of liposomal membranes, the issue of …

Polymersomes spanning from nano-to microscales: advanced vehicles for controlled drug delivery and robust vesicles for virus and cell mimicking

F Meng, Z Zhong - The Journal of Physical Chemistry Letters, 2011 - ACS Publications
Polymersomes provide a highly promising platform for mimicking biological membranes as
well as for controlled delivery of various pharmaceuticals and biopharmaceuticals. The …

Polymersomes and their applications in cancer delivery and therapy

L Guan, L Rizzello, G Battaglia - Nanomedicine, 2015 - Taylor & Francis
Polymersomes have been proposed as a platform for drug delivery systems since late 90s.
They are exploited to deliver hydrophilic and/or hydrophobic therapeutic and diagnostic …

Efficient Encapsulation of Plasmid DNA in pH‐Sensitive PMPC–PDPA Polymersomes: Study of the Effect of PDPA Block Length on Copolymer–DNA Binding Affinity

H Lomas, J Du, I Canton, J Madsen… - Macromolecular …, 2010 - Wiley Online Library
We report the self‐assembly of a series of amphiphilic diblock copolymers comprising a
biocompatible, hydrophilic block, poly (2‐methacryloyloxyethyl phosphorylcholine)(PMPC) …

Aqueous Self‐Assembly of Purely Hydrophilic Block Copolymers into Giant Vesicles

SM Brosnan, H Schlaad… - Angewandte Chemie …, 2015 - Wiley Online Library
Self‐assembly of macromolecules is fundamental to life itself, and historically, these systems
have been primitively mimicked by the development of amphiphilic systems, driven by the …

Molecular engineering of polymersome surface topology

L Ruiz-Pérez, L Messager, J Gaitzsch, A Joseph… - Science …, 2016 - science.org
Biological systems exploit self-assembly to create complex structures whose arrangements
are finely controlled from the molecular to mesoscopic level. We report an example of using …

Polymersomes: a synthetic biological approach to encapsulation and delivery

M Massignani, H Lomas, G Battaglia - Modern techniques for nano-and …, 2010 - Springer
Compartmentalization, ie the ability to create controlled volumes and separate molecules
one from another is possibly the most important requisite for complex manipulations. Indeed …