Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Hemorrhagic transformation in ischemic stroke and the role of inflammation

E Spronk, G Sykes, S Falcione, D Munsterman… - Frontiers in …, 2021 - frontiersin.org
Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology

H Chen, Y He, S Chen, S Qi, J Shen - Pharmacological Research, 2020 - Elsevier
Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Modulatory mechanisms of the NLRP3 inflammasomes in diabetes

S Ding, S Xu, Y Ma, G Liu, H Jang, J Fang - Biomolecules, 2019 - mdpi.com
The inflammasome is a multiprotein complex that acts to enhance inflammatory responses
by promoting the production and secretion of key cytokines. The best-known inflammasome …

[HTML][HTML] Age-related macular degeneration: role of oxidative stress and blood vessels

Y Ruan, S Jiang, A Gericke - International journal of molecular sciences, 2021 - mdpi.com
Age-related macular degeneration (AMD) is a common irreversible ocular disease
characterized by vision impairment among older people. Many risk factors are related to …

[HTML][HTML] The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke

G Xu, F Dong, L Su, ZX Tan, M Lei, L Li, D Wen… - Biomedicine & …, 2024 - Elsevier
Stroke is a prevalent cerebrovascular condition with a global impact, causing significant
rates of illness and death. Despite extensive research, the available treatment options for …

[HTML][HTML] METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis

Y Li, J Li, Q Yu, L Ji, B Peng - Neurobiology of disease, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) plays a crucial role in ischemic stroke, whereas the role
of methyltransferase-like 14 (METTL14) in ischemic stroke remains unknown. A model of …

Edaravone dexborneol provides neuroprotective benefits by suppressing NLRP3 inflammasome-induced microglial pyroptosis in experimental ischemic stroke

R Hu, J Liang, L Ding, W Zhang, X Liu, B Song… - International …, 2022 - Elsevier
Edaravone dexborneol (EDB) is a traditional prescription that consists of two components,
edaravone and (+)-borneol, which have synergistic antioxidant and anti-inflammatory …

New insights on NLRP3 inflammasome: mechanisms of activation, inhibition, and epigenetic regulation

T Kodi, R Sankhe, A Gopinathan… - Journal of Neuroimmune …, 2024 - Springer
Inflammasomes are important modulators of inflammation. Dysregulation of inflammasomes
can enhance vulnerability to conditions such as neurodegenerative diseases …