Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

The guanylate binding protein (GBP) family of interferon‐inducible GTP ases promotes
antimicrobial immunity and cell death. During bacterial infection, multiple mouse Gbps …

Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

The gamma-interferon (IFNγ)-inducible guanylate-binding proteins (GBPs) promote host
defense against gram-negative cytosolic bacteria in part through the induction of an …

Toxoplasma gondii is an intracellular protozoan parasite of global importance that can
remarkably infect, survive, and replicate in nearly all mammalian cells. Notably, 110 years …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Cell-autonomous immunity is essential for host organisms to defend themselves against
invasive microbes. In vertebrates, both the adaptive and the innate branches of the immune …

The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

The parasitophorous vacuole is a unique replicative niche for apicomplexan parasites,
including Toxoplasma gondii. Derived from host plasma membrane, the vacuole is rendered …