Since the discovery of antimicrobial peptide responses 40 years ago, the fruit fly Drosophila
melanogaster has proven to be a powerful model for the study of innate immunity. Early work …

The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

The fruit fly, Drosophila melanogaster, has helped us to understand how innate immunity is
activated. In addition to the Toll receptor and the Toll signaling pathway, the Drosophila …

Immune defense and reproduction are physiologically and energetically demanding
processes and have been observed to trade off in a diversity of female insects. Increased …

The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria.
During the last two decades, significant progress has been made in identifying the …

Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are
found in intellectual disability (ID) and autism spectrum disorders (ASD) patients. Here, we …

Steroid hormones are responsible for the coordinated regulation of many aspects of
biological processes in multicellular organisms. Since the last century, many studies have …

The vertebrate protein STING, an intracellular sensor of cyclic dinucleotides, is critical to the
innate immune response and the induction of type I interferon during pathogenic infection …

Microbe-derived acetate activates the Drosophila immunodeficiency (IMD) pathway in a
subset of enteroendocrine cells (EECs) of the anterior midgut. In these cells, the IMD …

Drosophila melanogaster has been extensively used to study the humoral arm of innate
immunity because of the developmental and functional parallels with mammalian innate …