Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

At sites of vascular injury, platelets come into contact with subendothelial collagen, which
triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib …

Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

Hemostasis and pathological thrombus formation are dynamic processes that require a co-
ordinated series of events involving platelet membrane receptors, bidirectional intracellular …

Platelet adhesion on and activation by components of the extracellular matrix are crucial to
arrest post‐traumatic bleeding, but can also harm tissue by occluding diseased vessels …