Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis
and is a major challenge to current treatments. Cancer cells commonly evade apoptosis …

Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

The BCl-2 family has long been identified for its role in apoptosis. Following the initial
discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous …

Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …

Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also …