Expanded encyclopaedias of DNA elements in the human and mouse genomes
The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate …
govern the timing, magnitude, and cellular context of their production. To better delineate …
Molecular and cellular mechanisms that regulate human erythropoiesis
To enable effective oxygen transport,∼ 200 billion red blood cells (RBCs) need to be
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …
[HTML][HTML] The changing mouse embryo transcriptome at whole tissue and single-cell resolution
During mammalian embryogenesis, differential gene expression gradually builds the identity
and complexity of each tissue and organ system. Here we systematically quantified mouse …
and complexity of each tissue and organ system. Here we systematically quantified mouse …
Segmentation and genome annotation algorithms for identifying chromatin state and other genomic patterns
Segmentation and genome annotation (SAGA) algorithms are widely used to understand
genome activity and gene regulation. These algorithms take as input epigenomic datasets …
genome activity and gene regulation. These algorithms take as input epigenomic datasets …
Distinct properties and functions of CTCF revealed by a rapidly inducible degron system
CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor implicated in a
wide range of functions, including genome organization, transcription activation, and …
wide range of functions, including genome organization, transcription activation, and …
CTCF and transcription influence chromatin structure re-configuration after mitosis
During mitosis, transcription is globally attenuated and chromatin architecture is dramatically
reconfigured. We exploited the M-to G1-phase progression to interrogate the contributions of …
reconfigured. We exploited the M-to G1-phase progression to interrogate the contributions of …
Chromatin-state barriers enforce an irreversible mammalian cell fate decision
Stem and progenitor cells have the capacity to balance self-renewal and differentiation.
Hematopoietic myeloid progenitors replenish more than 25 billion terminally differentiated …
Hematopoietic myeloid progenitors replenish more than 25 billion terminally differentiated …
An NFIX-mediated regulatory network governs the balance of hematopoietic stem and progenitor cells during hematopoiesis
The transcription factor (TF) nuclear factor IX (NFIX) is a positive regulator of hematopoietic
stem and progenitor cell (HSPC) transplantation. Nfix-deficient HSPCs exhibit a severe loss …
stem and progenitor cell (HSPC) transplantation. Nfix-deficient HSPCs exhibit a severe loss …
In situ phagocyte-mediated deep tumor penetration assisted by ApoA-1 mimetic peptide-modified silicasome
J Wang, X Peng, J Wei, Y Dai, S Huang, D Deng, Z Fan… - Nano Today, 2023 - Elsevier
Deep tumor penetration of therapeutic drugs remains challenging for the ablation of solid
tumors, which impedes their clinical translation. In situ cell-mediated delivery is an efficient …
tumors, which impedes their clinical translation. In situ cell-mediated delivery is an efficient …
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes
Knowledge of locations and activities of cis-regulatory elements (CREs) is needed to
decipher basic mechanisms of gene regulation and to understand the impact of genetic …
decipher basic mechanisms of gene regulation and to understand the impact of genetic …